Glossary of Terms Related to FYCOMPA®

Here are some words that you may hear. Understanding these words can help you understand your condition.

Add-on drug:

A medication taken along with another medication to treat the same problem.

AMPA receptor:

AMPA receptors help receive signals on nerve cells. When they receive too many signals, a seizure can happen.

Antiepileptic drug (AED):

A medication used to treat different types of seizures. Also may be called an anticonvulsant.


A warning you may feel before a seizure. It is a strange feeling or sense that lets you know a seizure is about to happen. This is different for each person.

Complex partial seizure:

A seizure that starts in one part of the brain. Your awareness is affected.


A measure of how a medication helps treat a condition or symptoms.


A group of related disorders defined by having seizures.

Focal seizure:

Another term that means “partial-onset seizure.”

Generalized seizure:

A seizure that starts in more than one part of your brain. Also called an idiopathic generalized seizure (IGE).

Grand mal seizure:

Another term that means "primary generalized tonic-clonic seizure (PGTC)."

Idiopathic generalized epilepsy:

A type of epilepsy that can cause many different types of seizures, including primary generalized tonic-clonic seizures.


A nerve cell. The brain has billions of neurons. They send signals to each other.

Partial-onset seizures:

A seizure that starts in one part of the brain. Also known as focal seizures.

Primary generalized tonic-clonic seizures:

This type of seizure starts in more than one place in the brain at the same time. During the seizure, muscles become stiff and then make jerking movements. Also known as grand mal seizures.


A change in signals in the brain. It affects how you feel, move, act, or think for a brief period of time.

Side effects:

Negative effect from medication or therapy.

Simple partial seizure:

A seizure that starts in one part of the brain. Your awareness is not affected.

Tonic-clonic seizure:

A seizure that causes muscles to become stiff and then make jerking movements.


Things that can cause a seizure to happen. Two examples are flashing lights and stress.

Uncontrolled seizures:

When you continue to have seizures despite receiving treatment.

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Indication and Important Safety Information

Important Safety Information

FYCOMPA may cause mental (psychiatric) problems, including: new or worse aggressive behavior (including homicidal behavior), hostility, anger, anxiety, or irritability; being suspicious or distrustful (believing things that are not true); seeing objects or hearing things that are not there; confusion; difficulty with memory; other unusual or extreme changes in behavior or mood. Tell your healthcare provider right away if you have any new or worsening mental problems while taking FYCOMPA.

FYCOMPA is a prescription medicine used in people with epilepsy aged 12 and older alone or with other medicines to treat partial-onset seizures with or without secondarily generalized seizures and with other medicines to treat primary generalized tonic-clonic seizures

Pay attention to any changes especially sudden changes in mood, behaviors, thoughts, or feelings and keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Do not stop FYCOMPA without first talking with your healthcare provider. Stopping suddenly can cause serious problems and can cause you to have seizures more often.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking FYCOMPA with certain other medicines can cause side effects or reduce either drug’s benefit. These medicines include: birth control, carbamazepine, phenytoin, oxcarbazepine, rifampin, and St. John’s Wort.

What should I avoid while taking FYCOMPA?
Do not drive, operate heavy machinery, or do other dangerous activities until you know how FYCOMPA affects you. FYCOMPA may make you dizzy, sleepy, or tired. Do not drink alcohol or take other medicines that make you sleepy or dizzy until you talk to your healthcare provider. FYCOMPA taken with alcohol or medicines that cause sleepiness or dizziness may make your sleepiness or dizziness worse. FYCOMPA when taken with alcohol may also make your mood worse, increase anger, confusion, and depression.

FYCOMPA may cause other serious side effects, including: Dizziness, vertigo (sense of spinning), and problems walking normally. You may have problems walking normally if you are unsteady because you feel dizzy. These symptoms can increase when your dose of FYCOMPA is increased. Your risk of feeling dizzy and having problems walking normally may be higher if you are elderly; Sleepiness and tiredness; Increased risk of falls. Taking FYCOMPA can increase your chance of falling. These falls can cause serious injuries. Your risk of falling may be higher if you are elderly; A serious allergic reaction that may affect your skin or other parts of your body such as your liver, kidneys, heart, or blood cells. This allergic reaction can be life-threatening and can cause death. Call your healthcare provider right away if you have: a skin rash, hives; fever or swollen glands that do not go away; swelling of your face; shortness of breath; swelling of the legs; yellowing of the skin or whites of the eyes; or dark urine

The most common side effects of FYCOMPA include: dizziness; sleepiness; tiredness; irritability; falls; nausea and vomiting; weight gain; vertigo (sense of spinning); problems walking normally; problems with muscle coordination; headache; bruising; abdominal pain; anxiety

FYCOMPA is a controlled substance (CIII) because it can be abused or lead to drug dependence. Keep FYCOMPA in a safe place to protect it from theft and never give it to anyone else because it may harm them. Selling or giving away FYCOMPA is against the law.

Prescribing Information and Medication Guide for FYCOMPA.