Primary Generalized Tonic-clonic
(Grand Mal) Seizures

FYCOMPA® is a prescription medicine that is used with other medications to treat primary generalized tonic-clonic seizures (also called grand mal seizures) in people who are 12 years of age and older

What is a primary generalized tonic-clonic seizure (also called grand mal seizure)?


The name “primary generalized tonic-clonic seizure" can be hard to understand. To help you understand it, take a look at the meaning of each word:

Primary means the seizure happens without another one happening first.

Generalized means it starts in more than one place in the brain.

Tonic is the first stage of the seizure, when the muscles stiffen.

Clonic is the second stage, when the muscles begin to jerk rapidly.

 

[back to the top]

What are the other symptoms?

Along with the tonic phase and the clonic phase, certain symptoms can happen before, during, and after a seizure.

Before
  • Feeling a warning. This is different for each person, and may not happen to everyone. It is a strange feeling or sense that lets you know a seizure is about to happen
During (tonic-clonic stage)
  • Crying out, because of air being forced out of the lungs
  • Losing awareness
  • Losing control of the bowels or bladder
After
  • Feeling confused
  • Loss of energy
  • Getting a headache
Before During
(tonic-clonic stage)
After
  • Feeling a warning. This is different for each person, and may not happen to everyone. It is a strange feeling or sense that lets you know a seizure is about to happen
  • Crying out, because of air being forced out of the lungs
  • Losing awareness
  • Losing control of the bowels or bladder
  • Feeling confused
  • Loss of energy
  • Getting a headache

[back to the top]


How can you manage them?

Everyone has different responses to medication. Some people take medication but still have seizures. When this happens, they are called “uncontrolled seizures.”

If you experience primary generalized tonic-clonic seizures and need additional control, ask your doctor if FYCOMPA may be right for you.

Not sure if your seizures are under control? Take the Seizure Treatment Quiz.
[back to the top]

Next: Learn About Partial-onset Seizures

Indication and Important Safety Information

Important Safety Information

FYCOMPA may cause mental (psychiatric) problems, including: new or worse aggressive behavior (including homicidal behavior), hostility, anger, anxiety, or irritability; being suspicious or distrustful (believing things that are not true); seeing objects or hearing things that are not there; confusion; difficulty with memory; other unusual or extreme changes in behavior or mood. Tell your healthcare provider right away if you have any new or worsening mental problems while taking FYCOMPA.

FYCOMPA is a prescription medicine used in people with epilepsy aged 12 and older alone or with other medicines to treat partial-onset seizures with or without secondarily generalized seizures and with other medicines to treat primary generalized tonic-clonic seizures

Pay attention to any changes especially sudden changes in mood, behaviors, thoughts, or feelings and keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Do not stop FYCOMPA without first talking with your healthcare provider. Stopping suddenly can cause serious problems and can cause you to have seizures more often.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking FYCOMPA with certain other medicines can cause side effects or reduce either drug’s benefit. These medicines include: birth control, carbamazepine, phenytoin, oxcarbazepine, rifampin, and St. John’s Wort.

What should I avoid while taking FYCOMPA?
Do not drive, operate heavy machinery, or do other dangerous activities until you know how FYCOMPA affects you. FYCOMPA may make you dizzy, sleepy, or tired. Do not drink alcohol or take other medicines that make you sleepy or dizzy until you talk to your healthcare provider. FYCOMPA taken with alcohol or medicines that cause sleepiness or dizziness may make your sleepiness or dizziness worse. FYCOMPA when taken with alcohol may also make your mood worse, increase anger, confusion, and depression.

FYCOMPA may cause other serious side effects, including: Dizziness, vertigo (sense of spinning), and problems walking normally. You may have problems walking normally if you are unsteady because you feel dizzy. These symptoms can increase when your dose of FYCOMPA is increased. Your risk of feeling dizzy and having problems walking normally may be higher if you are elderly; Sleepiness and tiredness; Increased risk of falls. Taking FYCOMPA can increase your chance of falling. These falls can cause serious injuries. Your risk of falling may be higher if you are elderly; A serious allergic reaction that may affect your skin or other parts of your body such as your liver, kidneys, heart, or blood cells. This allergic reaction can be life-threatening and can cause death. Call your healthcare provider right away if you have: a skin rash, hives; fever or swollen glands that do not go away; swelling of your face; shortness of breath; swelling of the legs; yellowing of the skin or whites of the eyes; or dark urine

The most common side effects of FYCOMPA include: dizziness; sleepiness; tiredness; irritability; falls; nausea and vomiting; weight gain; vertigo (sense of spinning); problems walking normally; problems with muscle coordination; headache; bruising; abdominal pain; anxiety

FYCOMPA is a controlled substance (CIII) because it can be abused or lead to drug dependence. Keep FYCOMPA in a safe place to protect it from theft and never give it to anyone else because it may harm them. Selling or giving away FYCOMPA is against the law.

Prescribing Information and Medication Guide for FYCOMPA.